Wireless Hepatitis B Test Kit Completes Screening and Data Collection in One Step

Hepatitis B, a significant global health concern, is responsible for chronic liver diseases like cirrhosis and liver cancer which is one of the most common cancers worldwide. The challenge with hepatitis B is that most carriers are asymptomatic, remaining unaware of their infection, which can lead to its unintentional spread. Thus, early diagnosis is vital to halt the spread, initiate timely treatment, and reduce the risk of liver complications primarily caused by the hepatitis B virus. However, conventional tests for hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) are complex, requiring specialized skills and large, expensive machine-based assays typically found in major hospitals. To overcome the problem of inadequate access to screening for Hepatitis B, researchers have developed a wireless, point-of-care test for the Hepatitis B Virus that can make diagnosis simpler and faster.

Researchers from Chulalongkorn University (Bangkok, Thailand) have developed a testing kit that enables healthcare providers in smaller medical facilities or public health centers to independently conduct hepatitis B screenings. This approach simplifies the screening process, yielding results comparable to those of sophisticated machine-based tests. The kit utilizes an electrochemical biosensor based on the specific interaction between antigens and antibodies. The presence of the hepatitis B virus triggers a detectable change in electric current through amperometric detection. This change in current, correlating with the virus’s presence, offers a semi-quantitative measurement of the antigen’s concentration.

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