NSTDA and Chula Dentistry Introduce Toothpaste Prototype to Improve Oral Health and Mineral Replenishment for Children

The Assistive Technology and Medical Devices Research Center (A-MED), a division under the National Science and Technology Development Agency (NSTDA), Ministry of Higher Education, Science, Research and Innovation, together with the Faculty of Dentistry, Chulalongkorn University, have unveiled an innovative toothpaste prototype with nano-hydroxyapatite that helps to replenish minerals and strengthen tooth enamel.  

The project aims to promote and develop oral health and dental care products to improve the quality of life and oral healthcare for Thai people, as well as address disparities among consumers. By fostering the development of dental advancements by Thai dentists and academics, the collaboration aims to strengthen Thailand’s medical sector and reduce dependence on imported resources. The press conference to showcase the toothpaste prototype took placed on May 30, 2023 at the Faculty Executive Committee meeting room, Vajwittayawat Building, Faculty of Dentistry, Chulalongkorn University. 

Dr. Kitti Wongthavarawat, Head of the Health Innovation and Information Research Team, Assistive Technology and Medical Devices Research Center (A-MED), explained that when dental caries show up in children, it is the beginning of a series of long-term oral health issues. Presently, over 50% of Thai children currently suffer from tooth decay, and more than 60% of adults suffer from gingivitis due to limited access to adequate dental treatment. The nano-hydroxyapatite toothpaste prototype is the result of collaborative research, development, testing, design, and production of toothpaste products for the treatment of life-impeding oral health issues, such as early tooth decay, which usually happens because of lack of regular good oral health care. 

Development of the nano-hydroxyapatite materials was jointly carried out by the research teams from A-MED, NSTDA, and the Faculty of Dentistry at Chulalongkorn University. This novel material was created via a mechanical chemical method and has a structure similar to human bones and teeth. Nano-hydroxyapatite can be used as a component in toothpaste due to its compatibility with human tissues and capability to promote tooth enamel remineralization. By focusing on nano-sized hydroxyapatite, Thai researchers can help reduce reliance on imports, improve access to domestically manufactured high-quality medical materials, and maintain international medical standards that align with BCG medical device policy objectives. 

“The official launch of this prototype toothpaste marks another significant milestone in the two organizations’ successful partnership, as both collaborate to develop advanced preparation techniques for nano-hydroxy powder. By enabling the rapid formation of calcium phosphate from calcium and phosphate ions, which can precipitate onto the tooth surface, the addition of apatite in the toothpaste enhances its ability to restore minerals in the enamel layer. This enhancement elevates the overall quality of the toothpaste,” Prof. Dr. Pornchai Jansisyanont, Dean of the Faculty of Dentistry, concluded. 

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